Generic Name: Recombinant Human Interleukin- 18

English Name: Recombinant Human Interleukin -18

Abbreviation: Human IL-18 or IL-18

Expression host: E. coli

Nature: Monomer

Tag: No tag

Uniprot ID: Q14116-1(Tyr37 - Asp193)

2、Product Specifications/Article Number ：

This product is available in the following specifications: 20μg / 100μg / 500μg . We can also provide customized specifications based on the actual needs of customers.

SKU: GMP-A 23 18.

3、Quality Control：

Appearance: Colorless clear liquid

Purity (SDS-PAGE): >95%

Purity (SEC-HPLC): >95%

Purity (RP-HPLC): >95%

Biological activity (KG-1 cell IFN-γ induction method, EC50): < 20 ng/ ml

Bacterial endotoxin:<10EU/mg＜10EU/mg

HCD＜0.2ng/μg

Mycoplasma: Negative

4、Diagram (key quality control items)）：

Figure 1 : SDS-PAGE

Figure 2 : Biological Activity

Figure 3 : SEC- HPLC Purity

Figure 4 : RP- HPLC Purity

5、Storage conditions：

-20℃, no repeated freezing and thawing.

6、Background：

Recombinant human IL- 18 exhibits biological activity in monomeric form, and its biological effects are closely linked to those of IL-12. It can promote T cell proliferation, Th1 cell clone reactants to produce cytokines, enhance NK cell cytotoxicity, cause endotoxin-induced liver damage, and act as a neuroimmunomodulator, participating in neuro-endocrine-immune network regulation and skin immunity.